Cáncer de mama en hombres: revisión de casos en el Hospital Regional de Talca / Breast cancer in men: review of cases at "Hospital Regional de Talca"

Breast cancer in men is a rare pathology. The most common clinical presentation is a palpable and painless retroareolar nodule. In men, it is a rare pathology, there are few studies on the matter, where breast cancer trials frequently exclude men. Objective: to present the incidence of breast cancer in men from the "Regional Hospital of Talca" Method: Retrospective and descriptive study of cases of breast cancer in men who have been treated and followed up in the Breast Pathology Unit of the Regional Hospital of Talca from January 1, 2011 to December 31, 2021.Results: There were 9 cases of breast cancer in men. Average age at diagnosis was 63 years, all patients were 50 years of age or older. One hundred percent of patients consulted for a self-palpable breast nodule. Average size on physical examination was 30 mm. The most frequent histology was invasive ductal carcinoma (56%), followed by invasive tubular carcinoma (22%) and ductal carcinoma in situ (11%). Immunohistochemistry was 100% positive for estrogen and progesterone receptor. Surgery in 56% of cases was total mastectomy with axillary dissection, and in 33% it was total mastectomy alone. 4 patients underwent adjuvant treatment with chemotherapy, and just one required a combination of chemotherapy and radiotherapy. During follow-up, only 2 patients died. Conclusion. Breast cancer in men is not very prevalent and the management is extrapolated from large studies in women, we believe that it is essential to have studies in male patients, to really have clarity on the behavior and evolution of the disease.

Carcinoma papilar intraquístico asociado a adenocarcinoma ductual infiltrante en un hombre: reporte de un caso / Papillary intra cyst carcinoma associated with ductal adenocarcinoma in a man: case report

El carcinoma papilar intraquístico es un subtipo de carcinoma ductal no invasivo, puede estar asociado o no acarcinoma in situ y a carcinoma infiltrante, es una patología poco frecuente por lo tanto su aparición en hombres es extremadamente rara. El tratamiento en estos casos es equivalente al carcinoma de mama en mujeres, se debate entre mastectomía simple o mastectomía parcial más radioterapia. Presentamos el caso de un hombre a quien se diagnostica preoperatoriamente con un carcinoma papilar y se realiza mastectomía simple más ganglio centinela.

The papillary intra cyst carcinoma is a sub type of ductal no invasive carcinoma, it can be or not associated to in situ carcinoma and to infiltrant carcinoma, is a pathology less frequent, for these reason his apparition in men is extremely rare. The treatment is equivalent to the breast carcinoma in women, debated between simple mastectomy and partial mastectomy with radiation therapy. We present a clinical case of a man with pre operative diagnostic with a papillary carcinoma and realized simple mastectomy with sentinel node.

Cáncer de mama bilateral en hombre / Bilateral breast cancer in men

El cáncer de mama en hombres representa menos del 1% de los cánceres en el sexo masculino y casi el 1% de los cánceres de mama. Existe debido a su muy baja incidencia una falta de estudios clínicos aleatorizados. Desde el año 2008 hasta la fecha hemos diagnosticado cuatro cánceres en hombres, las edades comprendidas entre 49 y 61 años,correspondiendo a estadios IIB (2), in situ bilateral (1), IIIB(1), histológicamente eran: dos carcinoma ductal infiltrante, un Paget con nódulo palpable y un bilateral. El presente trabajo pretende dar a conocer el caso de un paciente masculino diagnosticado y tratado en nuestra institución, con cáncer de mama bilateral

The breast cancers in the men represent less than 1% of all cancers in the male population, and only 1% of all the breast cancers. Because his low incidence, there are absence of a randomized clinical studies. Since the 2008 years to the present, we were diagnoses for men breast cancers in the age between 49 and 61 years old. 2 corresponded to IIB stage, bilateral in situ (1) stage IIB (1), histological there are: 2 ductal and infiltrante, one Paget disease with palpable node an one bilateral. The present work is known a clinical case of male patient diagnoses and treatment in our institution with bilateral breast cancer

Male breast cancer in Indian patients: Is it the same.

Background: Cancer of the male breast accounts for about 1% of all malignancies in men and 1% of all breast cancers. Poor level of awareness often results in late presentation and delayed diagnosis in our environment. This study was done to analyse the demographic data, management and survival of male breast cancers in Indian subset of patients and compare it with that of western literature. Materials and Methods: A 10 year (2001-2010) retrospective study of all male breast cancers was done. Data regarding the incidence, presentation, histopathology, stage and grade of tumor, management and outcome of patients were analysed. Results: 26 cases of male breast cancer were encountered. This comprised 0.4% of all breast cancers seen in our department during the 10 year period. The ages of patients ranged from 45-75 years with a mean age of 57 years. Family history was present in 4 patients. Clinically, symptoms included self-detected lump in 23 (88.5%) patients, nipple retraction in 12 (46.1%) and pain in 12 (46.1%). All cases were unilateral (16 on right, 10 on left). Disease most commonly involved central quadrant (9 patients). Grade 3 disease was found in 13 patients and Stage 3 disease was most commonly encountered (13 patients). None of our patients received neo adjuvant chemotherapy. 20 (76.9%) patients had modified radical mastectomy and 6 (23.1%) had radical mastectomy. Most of our patients were hormone receptor positive (21 patients). Bilateral orchidectomy, Adjuvant chemotherapy, Adjuvant radiotherapy and Tamoxifen were offered in 3 (11.5%), 16 (61.5%), 17 (65.4%) and 15 (57.7%) patients respectively. Follow up ranged from 1-59 months. Conclusion: Male breast cancer is rare in our centre. Late presentation with advanced disease is a common feature in our environment. Further multiinstitutional, prospective studies are needed for better understanding of management of male breast cancers in Indian subset of patients.

Carcinoma de mama en el hombre: revisión de casos / Breast carcinoma in men: report of cases

El objetivo del presente trabajo es presentar el comportamiento clínico patológico de 8 pacientes del sexo masculino con carcinoma de la mama, atendidos en el Instituto Oncológico "Dr. Luis Razetti" durante los años 2004-2005. El cáncer de mama en hombres representó el 2,33 por ciento, 37,5 por ciento fueron adenocarcinoma ductal infiltrante, 37,5 por ciento estadio IIIA, 87,5 por ciento se trató con mastectomías radicales modificadas, 57,25 por ciento expresan receptores de estrógenos, 28,57 por ciento sobre expresan Her2neu, 37,5 por ciento recibió adyuvancia, 62,5 por ciento con tamoxifeno, el seguimiento promedio fue de 44 meses, 37,5 por ciento de recaídas local y 62,5 por ciento están libres de enfermedad a los 5 años. El cáncer de mama en hombres es muy poco frecuente. El tratamiento primario es la cirugía, siguiendo los mismos lineamientos para la adyuvancia que en las mujeres.

The objective of the present work is analyzing the clinic pathologic status of 8 patients of sex male, attending in the Oncological Institute "Dr. Luis Razetti" during the 2004-2005 years. The breast cancer in male represented the 2.33 percent, in 37.5 percent of them were ductal infiltrante adenocarcinoma, 37.5 percent were state IIIA,87.5 percent were treated with surgery: Modified radical mastectomy, 57.25 percent express estrogen receptors, 28,57 percent over express Her2neu. 37.5 percent received adjuvant, 62.5 percent with tamoxifen, the average of periodic control was 44 month, and 37.5 percent of local recurrence and 62.5 percent of the patients are free of disease to 5 years. The breast cancer in male is less frequent. The primary treatment is surgery, with the same form to the adjuvant as in women.

Profile of breast cancer patients at a tertiary care hospital in north India.

Background and Aims: We carried out this study in order to know the epidemiology and management strategies for breast cancer patients in our patient population. Settings and Design: The epidemiological data pertaining to demography and risk factors for carcinoma breast were analyzed retrospectively in patients admitted to a tertiary care hospital of North India. Materials and Methods: Hospital records of 304 patients admitted for over a period of five years (January 1998 to December 2002) were used for data analysis. Statistical Analysis Used: Paired T-test . Results: Mean age of our female breast cancer patients was found to be lower compared to the western world, with an average difference of one decade. A majority of the patients were from a rural background and had a longer duration of symptoms compared to urban patients. Lump in the breast was a dominant symptom. Familial breast cancer was uncommon. Left sided breast cancer was slightly preponderant. Screening by mammography and staging procedures such as bone scan, Computed Tomography (CT) scan, and Magnetic Resonance Imaging (MRI) were sparsely used. The most common histology was infiltrating duct carcinoma. Conclusion: Modified radical mastectomy was found to be a safe operative procedure. Breast conservative surgery, although considered the gold standard in early breast cancer, was found unsuitable for our patients, due to the social background and lack of intensive radiotherapy and chemotherapy backup. Infiltrating duct carcinoma was more commonly associated with positive lymph nodes compared to other histopathologies. Cases operated by surgical oncologists had better axillary clearance. Neoadjuvant chemotherapy was used mainly by surgical oncologists suggesting a more rational approach toward the management of breast carcinoma.

Avaliação pela tomografia computadorizada das principais causas de hemorragias intracranianas não traumáticas / Evaluation for the computerized tomography of the main causes of not traumatic intracranial hemorrhages

Os autores revisam neste trabalho aspectos concernentes sobre uma patologia rara, mas que nos últimos anos apresentou aumento em sua incidência – o câncer de mama no sexo masculino. Fatores de risco e manifestações clínicas são abordados. Outrossim, aspectos de diagnóstico e estadiamento são levados em consideração. Embora com a incidência aumentando, ainda existem poucos protocolos estabelecidos para esta situação, fazendo com que várias condutas adotadas no câncer de mama em mulheres sejam empregadas nesta patologia. Diversos estudos estão sendo realizados, acerca da doença, atualmente. Seus resultados devem trazer novas luzes sobre como abordar, de maneira otimizada, os vários estágios desta neoplasia em pacientes do sexo masculino.

Cáncer de mama en hombres: aspectos clínicos fundamentales / Basic and clinical aspects of male breast cancer

El cáncer mama masculino es poco común. El número de casos de carcinomas de mama en hombres es inferior al 1 por ciento, siendo la edad promedio al momento del diagnóstico entre 60 y 70 años, aunque este puede afectar a hombres de todas las edades. Los factores que predisponen al riesgo parecen incluir la exposición a la radiación, la administración de estrógenos y las enfermedades relacionadas con el hiperestrogenismo, como la cirrosis o el síndrome de Klinefelter. También existen tendencias familiares que son definitivas, habiéndose observados una incidencia mayor entre los hombres que tienen familiares femeninas con cáncer de mama. La patología es similar a la del cáncer femenino, y el cáncer ductal infiltrante el tipo de tumor más común. El compromiso de los ganglios linfáticos y el patrón hematógeno de diseminación son similares a los que se encuentran en el cáncer de mama femenino. Entre los factores pronóstico que se han evaluado se encuentra la etapa al momento del diagnóstico y la presencia o ausencia de compromisos de ganglios linfáticos. La sobrevida general es similar a la de las mujeres con cáncer de mama. La creencia de que el cáncer de mama masculino tiene un pronóstico más precario puede proceder de la tendencia al diagnóstico en etapas más tardías.

Carcinoma de mama em homem: epidemiologia e tratamento / Male breast cancer: epidemiology and treatment

O câncer de mama no homem é doença rara e corresponde a 0,8% de todos os casos de carcinomas mamários. Ocorre com mais freqüência na sétima década de vida e em geral se apresenta como nódulo indolor localizado em região retroareolar. Os fatores de risco incluem idade, disfunção testicular, doença benigna da mama, história familiar positiva, excesso de exposição a hormônios femininos (síndrome de Klinefelter, drogas), radiação, raça negra, obesidade, elevado nível socioeconômico ou cultural, além de ser mais prevalente em famílias judaicas. A mamografia, a ultra-sonografia e a citologia aspirativa fazem parte dos exames complementares. A mutação do BRCA2 encontra-se associada à maior incidência da doença em homens. Devido à escassa quantidade de tecido glandular, o tratamento-padrão consiste em mastectomia radical modificada, radioterapia e, freqüentemente, quimioterapia. Em geral, os receptores de estrogênio e progesterona são positivos e, ainda hoje, o tamoxifeno é considerado o tratamento hormonal de eleição. O prognóstico é semelhante ao do câncer de mama da mulher, quando se equiparam parâmetros como idade, biologia tumoral e estadiamento.

Male breast cancer (MBC) is a rare disease and accounting for 0,8 % of all cases of breast cancer. Occurs more frequently on 7th decade of life and usually it presents painless subareolar lump. Risk factors include advanced age, testicular dysfunction, benign breast conditions, positive family history, excess exposure to female hormones (Klinefelter's syndrome, drugs), irradiation, black race, obesity, higher socioeconomic or educational status, besides to be more prevalent in Jewish origin. Mammography, sonography and aspiration cytology taken part in the complementary exams. BRCA2 mutation is associated with higher incidence of MBC. Due to the paucity of breast tissue in men, the standard treatment consists of modified radical mastectomy, radiotherapy and frequently chemotherapy. Generally estrogen and progesterone receptors are positives and the tamoxifeno still is the hormonal treatment selectioned. The prognostic is similar to the women breast cancer when to put on a level with parameters like age, biology tumor and stage.

Câncer de mama no homem: aspectos atuais / Male breast cancer: currents aspects

O câncer de mama no homem acomete menos de 1 por cento de todos os casos de carcinomas mamários, e é responsável por alta morbi-mortalidade. Ocorre mais frequentemente na 7ª década de vida e, geralmente, apresenta prognóstico reservado devido, principalmente, a estágio avançado no momento do diagnóstico. Devemos complementar o diagnóstico clínico com mamografia, ultra asonografia e citologia. O tratamento consiste em mastectomia radical modificada, radioterapia e, frequentemente quimioterapia. A hormonioterapia, geralmente, apresenta bons resultados. Atualmente utilizamos o tamoxifeno na dose de 20 mg/dia

Câncer de mama em homens: relato e seguimento de sete casos / Breasts neoplasms in man: seven case-reports

Os autores analisam e discutem 7 casos de pacientes masculinos portadores de neoplasia de mama. A idade media foi de 58,3, todos brancos. O tipo histológico predominante foi o carcinoma ductal. Quanto a sobrevida, os pacientes seguem em "follow-up", num intervalo que varia de 3 meses a 4 anos após a cirurgia(com exceção de um que evoluiu para óbito 4 anos após o diagnóstico inicial)...

Neoplasia maligna de mama em homens: análise retrospectiva de dezesseis casos / Malignant neoplasia in men: retrospective analysis of sixteen cases

Foram analisados retrospectivamente dezesseis casos de pacientes do sexo masculino, com diagnóstico histopatológico de neoplasia maligna de mama, tratados no Serviço de Cirurgia Geral do Hospital de Clínicas de Porto Alegre (HCPA) e no Serviço de Cirurgia Oncológica do Hospital Santa Rita (HSR) no período de julho de 1985 a julho de 1995. A média de idade dos pacientes foi de 63 anos. O tempo médio de evoluçäo da doença foi de 34 meses. Nódulo mamário foi o sintoma de apresentaçäo na maioria dos casos. A associaçäo com outras neoplasias ocorreu em 2 pacientes. A localizaçäo retroareolar foi encontrada em todos. O tamanho médio do tumor no momento do diagnóstico foi de 3,63cm. A cirurgia foi o tratamento principal e constituiu em mastectomia simples con esvaziamento axiliar. O carcinoma ductal invasor foi o tipo histológico mais prevalente (62 por cento). Nove pacientes apresentaram-se em estágio III ou IV no momento do diagnóstico. Baseado nessa casuística, os autores discutem aspectos clínicos, etiológicos e tratamento dessa neoplasia

Cáncer de mama en el hombre: análisis de 22 casos: pautas de diagnóstico y tratamiento / Mammary cancer in man: analysis of 22 cases

Se analizan 22 casos de pacientes de sexo masculino portadores de cáncer mamario quienes presentaban una edad promedio de 63 años (rango 50-80). En ninguno de ellos se detectó un claro factor de riesgo. En tres había antecedentes familiares de cáncer de mama en mujeres. Clínicamente se presentaron en E I el 27.2 por ciento, en E II 27.2 por ciento, E III 30 por ciento, E IV 12 por ciento. En general, la consulta fue tardía con un tiempo promedio de retraso de 10 meses. La anatomía patológica correspondió en 19 casos a la forma ductal infiltrante 2 ductales no infiltrantes y 1 ductal in situ no infiltrante. En ningún paciente se efectuó dosificación de receptores hormonales. El tratamiento locorregional consistió en cirugía más radioterapia. Predominó la mastectomía radical modificada en 12 casos, mastectomía en 6 y cuadrantectomía en 2. Dos casos se consideran no operables. Las técnicas y dosis de radiación fueron las convencionales. Los tratamientos sistémicos consistieron en tamoxifeno o poliquimiooterapia tipo CMF en los casos de adyuvancia y en tamoxifeno o poliquimioterapia tipo FAC en las formas metastásicas. Se concluye en la necesidad de la confirmación histológica de este tipo de tumor así como en la dosificación obligatoria de receptores hormonales para orientar con éstos la conducta terapéutica. En general, el tratamiento resulta similar a lo pautado en el cáncer mamario en la mujer